Antibody-directed Fibrinolysis

Antibody-Directed Phototherapy (ADP)

Photodynamic therapy (PDT) is a clinically-approved but rather under-exploited treatment modality for cancer and pre-cancerous superficial lesions. It utilises a cold laser or LED to activate a photochemical reaction between a light activated drug (photosensitiser-drug) and oxygen to generate cytotoxic oxygen species. These free radical species damage cellular components leading to cell death. ...

Antibody-Directed Cellularization of Heart Valve Implants

Introduction. Valvular heart disease is a common diagnosis worldwide, with many of these patients eventually needing an operative intervention. There are significant limitations to existing heart valve replacements, including their inability to grow with patients, a life-time anticoagulation therapy with mechanical valves, and progressive tissue degeneration with bioscaffolds. Tissue-engineerin...

Development of Antibody‐Directed Therapies: Quo Vadis?

Less is more: The efficacy of antibody-drug conjugates (ADCs) for cancer therapy is traditionally associated with cleavable linkers for payload release. Evidence now suggests that simpler constructs without cleavable moieties can afford more stable and effective ADCs.

Dysfunction of glomerular fibrinolysis in experimental antiglomerular basement membrane antibody glomerulonephritis.

Glomerular plasminogen activator inhibitor-1 (PAI-1) steady-state mRNA and bioactivity were increased after the induction of an augmented form of antiglomerular basement membrane (GBM) antibody glomerulonephritis. PAI-1 mRNA expression was noted at 6 h, peaking at 1 day, and although falling thereafter, remained higher than that of the control group through Day 17. PAI-1 mRNA expression correla...

Comparative Fibrinolysis